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Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis

Moses Njire1,2, Na Wang1,3, Bangxing Wang1

  • 1State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

Antimicrobial Agents and Chemotherapy
|April 26, 2017
PubMed
Summary

A new study identifies Asp67Asn substitution in Rv2783 as a pyrazinamide (PZA) resistance determinant in tuberculosis. This finding reveals Rv2783 as a PZA target, aiding in diagnosing PZA resistance and developing new tuberculosis drugs.

Keywords:
PNPaseantibiotic resistancedrug targetppGpppyrazinamidepyrazinoic acid

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