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Association Between Adiponectin and Insulin Resistance in Diabetic Urolithiasis
Dona Devasia1, Kavitha Meiyappan2, Palani Selvam Mohanraj1
1Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Oman Medical Journal
|April 26, 2017
Summary
Serum adiponectin levels are elevated in patients with diabetes mellitus and kidney stones. This finding may help understand the link between diabetes, adiponectin, and urolithiasis risk.
Area of Science:
- Endocrinology
- Nephrology
- Metabolic Diseases
Background:
- Urolithiasis prevalence is rising globally.
- Diabetes mellitus (DM) is linked to increased kidney stone risk due to insulin resistance.
- Adiponectin, an insulin-sensitizing cytokine, has unclear associations with kidney stones.
Purpose of the Study:
- To investigate serum adiponectin and insulin resistance in diabetic patients with urolithiasis compared to those without.
- To clarify the relationship between adiponectin, insulin, and kidney stone formation in diabetes.
Main Methods:
- Study included 60 patients with diabetes mellitus, divided into two groups: 30 with urolithiasis (Group A) and 30 without (Group B).
- Measured serum adiponectin, insulin, glucose, urea, creatinine, and 24-hour urinary calcium and phosphate levels.
Main Results:
- Serum adiponectin levels were significantly higher in diabetic patients with urolithiasis (Group A) versus controls (Group B).
- 24-hour urinary calcium and phosphate levels were also significantly increased in Group A.
- No significant difference in serum insulin or insulin resistance (HOMA-IR) was observed between groups. A negative correlation between serum adiponectin and insulin was noted in Group A.
Conclusions:
- Serum adiponectin levels are elevated in patients with diabetes mellitus and co-existing urolithiasis.
- Increased urinary calcium and phosphate may contribute to stone formation in this population.
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