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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

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The Search for the Missing Heritability of Prostate Cancer

Patrick C Walsh¹

¹James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

European Urology

|April 27, 2017

Abstract:

Scientists and clinicians at Johns Hopkins have been working since 1987 to uncover the genetic pathogenesis of prostate cancer. A patient query about the hereditary nature of the disease led to data collection on family history, followed by segregation and linkage analyses. Collaborative investigations using next-generation sequencing to identify genetic variants associated with prostate cancer risk have revealed the significance of HOXB13, BRCA 1/2, and DNA repair mutations.

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