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A genetic risk score predicts cardiovascular events in patients with stable coronary artery disease

Morten Krogh Christiansen1, Mette Nyegaard2, Sanne Bøjet Larsen3

  • 1Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Faculty of Health, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

International Journal of Cardiology
|April 27, 2017
PubMed

Insights

A genetic risk score (GRS) helps predict future cardiovascular events in patients with coronary artery disease (CAD). Higher GRS is linked to increased risk, particularly for coronary revascularization procedures.

Area of Science:

  • Cardiovascular Genetics
  • Precision Medicine

Background:

  • Genetic risk scores (GRSs) show potential for predicting cardiovascular risk in general populations.
  • Evidence linking GRS to recurrent cardiovascular events in established coronary artery disease (CAD) patients remains inconsistent.

Purpose of the Study:

  • To investigate the predictive value of a GRS for recurrent cardiovascular events in high-risk, stable CAD patients.
  • To determine if GRS can stratify risk within this specific patient cohort.

Main Methods:

  • Genotyped 879 high-risk stable CAD patients, creating a GRS from 45 CAD-associated SNPs.
  • Categorized patients into high and low GRS groups based on the median.
  • Utilized national Danish registries to track recurrent cardiovascular events, including myocardial infarction, coronary revascularization, and cardiovascular death.

Main Results:

  • Patients with a high GRS had a significantly higher cumulative incidence of the primary endpoint (composite of myocardial infarction, coronary revascularization, and cardiovascular death) at 1 and 3 years compared to low-GRS patients.
  • The adjusted hazard ratio for the primary endpoint was 1.50 (95% CI 1.00-2.25) for high-GRS individuals.
  • A high GRS was most strongly associated with an increased risk of coronary revascularization (adjusted HR 2.10 [95% CI 1.08-4.07]).

Conclusions:

  • A GRS is a valuable tool for predicting recurrent cardiovascular events in high-risk patients with stable CAD.
  • The predictive power of GRS in this population is primarily driven by its association with coronary revascularization events.
Abstract

Keywords:
Coronary artery diseaseGenetic predisposition to diseaseGeneticsMyocardial infarctionRisk score

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