Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sanger Sequencing01:57

Sanger Sequencing

776.2K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
776.2K
RNA-seq03:21

RNA-seq

12.3K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
12.3K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

13.3K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
13.3K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Next-generation Sequencing03:00

Next-generation Sequencing

99.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
99.6K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of the family in youth psychiatric readmission: a scoping review.

European child & adolescent psychiatry·2026
Same author

"Are You Okay, Honey?": Recognizing Emotions Among Couples Managing Diabetes in Daily Life Using Multimodal Real-World Smartwatch Data.

Sensors (Basel, Switzerland)·2026
Same author

Automatic Item Generation Measurement Models Respecting the Stochastic Sampling Space for Cross-Classified and Two-Level Sampling of Subjects and Incidentals.

Applied psychological measurement·2026
Same author

We-disease Model: A conceptualization of couples' dyadic coping when dealing with chronic physical or mental illness.

Health psychology open·2026
Same author

Self-Esteem and Supportive Dyadic Coping in Intimate Relationships.

Personality & social psychology bulletin·2026
Same author

Differences in Dyadic Coping Between Couples Facing Early-Stage Dementia Compared with Couples Facing a Visual Impairment and Healthy Couples.

Journal of clinical psychology in medical settings·2026
Same journal

Adverse and positive childhood experiences in relation to adolescent mental health: sequential indirect associations.

Frontiers in psychology·2026
Same journal

Personality profiles and usage experience are associated with trust and dependence on generative AI: a latent profile analysis.

Frontiers in psychology·2026
Same journal

Editorial: Promoting replicability: empowering method and applied researchers in driving reliable results.

Frontiers in psychology·2026
Same journal

The mediating roles of the challenge appraisal in the relationship between the coach-athlete relationship and adolescent athletes' burnout.

Frontiers in psychology·2026
Same journal

Unpacking GenAI-enabled deep learning engagement: role perceptions, human-GenAI synergy strategies, and underlying mechanisms.

Frontiers in psychology·2026
Same journal

Violence exposure and cyberbullying among Chinese adolescents: the mediating role of moral disengagement.

Frontiers in psychology·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow
12:53

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow

Published on: June 14, 2017

11.3K

Analyzing Dyadic Sequence Data-Research Questions and Implied Statistical Models.

Peter Fuchs1, Fridtjof W Nussbeck1, Nathalie Meuwly2

  • 1Department of Psychology, Bielefeld UniversityBielefeld, Germany.

Frontiers in Psychology
|April 27, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces statistical models for analyzing observational data in romantic relationships and dyadic systems. It provides guidance for researchers on selecting appropriate models for medium-sized samples, enhancing the understanding of relationship dynamics.

Keywords:
DySeqbehavioral interactionsdyadic data analysisdyadic interactioninterval samplingobservational datarelationship researchsequence data

More Related Videos

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

4.3K
Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
09:14

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

7.6K

Related Experiment Videos

Last Updated: Mar 3, 2026

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow
12:53

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow

Published on: June 14, 2017

11.3K
Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

4.3K
Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
09:14

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

7.6K

Area of Science:

  • Social Psychology
  • Quantitative Psychology
  • Relationship Science

Background:

  • Observational data analysis is crucial for understanding dyadic systems, particularly romantic relationships.
  • Statistical models for dyadic observational data are underutilized.
  • Medium sample sizes (N=100 couples or less) present unique analytical challenges.

Purpose of the Study:

  • To present and compare statistical models for analyzing dyadic sequence data.
  • To provide guidance on model selection for researchers working with medium-sized dyadic datasets.
  • To facilitate the proper application of statistical models in empirical relationship research.

Main Methods:

  • Comparison of statistical models including Pearson Correlation, aggregated logit models, multi-level approaches, basic Markov models, hidden Markov models, mixture Markov models, and optimal matching.
  • Focus on models applicable to medium sample sizes (N ≤ 100 couples).
  • Hands-on approach linking models to specific research questions regarding dyadic interactions.

Main Results:

  • The study evaluates the applicability of various statistical models to different research questions about dyadic behavior.
  • It demonstrates how specific models address questions about behavioral associations, immediate reactions, underlying dyadic processes, and latent group patterns.
  • Recommendations are provided for model selection and data handling in dyadic research.

Conclusions:

  • The contribution aims to increase the accessibility and application of statistical models for dyadic observational data.
  • It equips researchers with tools and recommendations for analyzing relationship dynamics in medium-sized samples.
  • An accompanying R-package ('DySeq') is introduced to support empirical research.