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Published on: September 16, 2019
Netrin-1 in cancer: Potential biomarker and therapeutic target?
Umut Kefeli1, Aysegul Ucuncu Kefeli2, Devrim Cabuk1
11 Department of Medical Oncology, Kocaeli University School of Medicine, Kocaeli, Turkey.
Abstract:
Netrin-1, a laminin-related protein, is known to be involved in the nervous system development. Recently, Netrin-1's involvement in other processes such as cell adhesion, motility, proliferation, and differentiation that are important for the development of epithelial tissues has been described. In addition, Netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated-5 homolog, have been linked to apoptosis and angiogenesis. Since these properties are essential for tumor development, Netrin-1 and its receptors have been reported to promote tumorigenesis in many types of cancers. Here, we review the Netrin-1 mediated regulation of cancer, its potential use as a biomarker, and the targeting of the Netrin-1 pathway to treat cancers.
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