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Published on: December 2, 2022
In vitro effects of ambroxol on Cryptococcus adherence, planktonic cells, and biofilms
Qingtao Kong1,2, Xue Du3, Suyang Huang3
1Southern Medical University, Guangzhou, China.
Abstract:
The antifungal effects of ambroxol (Amb; the metabolite VIII of bromhexine) against Cryptococcus planktonic cells and mature biofilms were investigated in this study. Amb showed antifungal activity against planktonic cells and mature biofilms. Disk diffusion test similarly showed antifungal profile for planktonic cells. Furthermore, Amb was found to be synergetic with fluconazole against planktonic cells and reduced the adherence of cells to polystyrene. Our results suggest that Amb can inhibit cryptococcal cells and biofilms, indicating its potential role in the prevention and treatment of cryptococcosis.
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