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Malignant phosphaturic mesenchymal tumor with pulmonary metastasis: A case report
1Department of Orthopedic Surgery Department of Medical Oncology Department of Ultrasonography, the First Affiliated Hospital of China Medical University, Shenyang Department of Pathology, Fushun Hospital of Traditional Chinese Medicine, Fushun Department of Radiology and Key Laboratory of Diagnostic Imaging and Interventional Radiology, the First Affiliated Hospital of China Medical University Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, PR China.
Rationale:
Phosphaturic mesenchymal tumor (PMT) is a new tumor entity of soft tissue and bone tumor recently accepted by the World Health Organization, which typically causes the paraneoplastic syndrome of tumor-induced osteomalacia (TIO). The majority of PMTs follow a benign clinical course and local recurrence occurs in < 10% of cases, malignant PMTs with distant organ metastasis are extremely uncommon.
Patient Concerns:
We reported a 41-year-old woman who was diagnosed with PMT 10 years ago with a repeated recurrence and pulmonary metastasis.
Diagnoses:
Based on clinical manifestations, MRI scan, serum biochemical indicators evaluation, followed by histopathological examination, the patient was diagnosed as malignant PMT with pulmonary metastasis.
Interventions:
The patient was treated with calcium, phosphorus, and vitamin D after surgical resection and measured the serum ion concentrations every 3 months.
Outcomes:
The patient had a favorable outcome for 10 months without recurrence.
Lessons:
PMTs lack of characteristic histological morphology, some recurrence cases may appear benign morphologically; the malignant PMTs are easily overlooked. Patients with PMT should be carefully evaluated and monitored, in order to early identify its malignant potential.
Insights
Malignant phosphaturic mesenchymal tumors (PMTs) are rare and can be overlooked due to subtle morphology. Early identification and careful monitoring are crucial for managing these bone and soft tissue tumors.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Phosphaturic mesenchymal tumors (PMTs) are a newly recognized entity causing tumor-induced osteomalacia (TIO).
- Most PMTs are benign, with malignant transformation and metastasis being rare.
