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Signaling by Antibodies: Recent Progress

Stylianos Bournazos1, Taia T Wang1, Rony Dahan1

  • 1Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10065;

Annual Review of Immunology
|April 28, 2017
PubMed

IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

Keywords:
Fc receptorsIgGeffector functionimmunityimmunomodulationinflammation

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