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Updated: Mar 3, 2026
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
[Clinical Significance of Peripheral blood EB Virus Detection in NK/T Cell Lymphoma Patients]
Jing Zhang1, Lei Yue1, Ying-Lu Li2
1Department of Clinical Laboratorial Examination, The First Affiliated Hospital of Nanyang Medical College, Nanyang 473000, Henan Province, China.
Objective:
To explore the clinical significance of peripheral blood EB virus detection in NK/T cell lymphoma patients.
Methods:
The positive rate of EB virus and EBV-DNA in 85 cases of NK/T cell lymphoma was assayed; the correlation of positive rate of EB virus with clinical staging, short-term and long-term prognosis was analyzed.
Results:
The positive rate of EB virus in NK/T cell lymphoma was high (80.00%). The EBV-DNA copy number in peripheral blood leukocytes was higher than that in peripheral plasma (P<0.05), but there was no significant difference in EBV-DNA level between peripheral leukocytes and serum (P>0.05). The I-II stages ratio of patients in EBV+ group was significantly lower than that in EBV- group. The CR rate and ORR in EBV+ group was significantly lower than those in EBV- group, the 3 year OS rate and 3 year DFR in EBV+ group also was significantly lower than those in EBV- group.
Conclusion:
The detection of periphera blood EBV may be used as an reference indicator for anxiliary diagnosis of NK/T cell lymphoma and evaluation of prognosis for patients, thus possessing a certain value for clinical application.
