Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

537
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
537
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.7K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.7K
Overview of Systemic Arteries01:11

Overview of Systemic Arteries

2.2K
The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the...
2.2K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.5K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.5K
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

905
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
905
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

2.4K
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ChatGPT in the diagnosis and management of complex polyneuropathies: comparative analysis with neurologists using real-world cases.

NPJ digital medicine·2026
Same author

Sural/Radial Amplitude Ratio in Non-Length-Dependent Neuropathy (NLDN): A Call for More Standardized Methodology and Further Evaluation of Distal NLDN.

Muscle & nerve·2026
Same author

Prognostic Implications of SMARCA4, ARID1A, and Other BAF Mutations in Non-Small Cell Lung Cancer.

Cancer medicine·2025
Same author

Establishment of normal myofiber size distribution in children and young adults.

Journal of neuropathology and experimental neurology·2025
Same author

The Neuropathies of Vasculitis.

Neurologic clinics·2025
Same author

Unnerving Cough in CANVAS: Cough Hypersensitivity Despite Airway Nerve Depletion.

Lung·2025
Same journal

Ataxia Global Initiative recommend MRI end-points for clinical trials in ataxias.

Nature reviews. Neurology·2026
Same journal

Adaptive deep brain stimulation in Parkinson disease: clinical implementation and outlook.

Nature reviews. Neurology·2026
Same journal

Moving artificial intelligence from research to real-world clinical use in neurology.

Nature reviews. Neurology·2026
Same journal

Artificial intelligence in headache care.

Nature reviews. Neurology·2026
Same journal

Artificial intelligence could reshape research and care in disorders of consciousness.

Nature reviews. Neurology·2026
Same journal

Christina Kim: functional and biochemical mapping of neural circuits.

Nature reviews. Neurology·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

10.1K

The nonsystemic vasculitic neuropathies.

Michael P Collins1, Robert D Hadden2

  • 1Department of Neurology, Medical College of Wisconsin, 9200 W Wisconsin Ave., Milwaukee, Wisconsin, Wisconsin 53226, USA.

Nature Reviews. Neurology
|April 28, 2017
PubMed
Summary
This summary is machine-generated.

Nonsystemic vasculitic neuropathy (NSVN) is a nerve-only vasculitis requiring biopsy for diagnosis. Treatment with corticosteroids and immunosuppressants may improve outcomes, though relapses and chronic pain can occur.

More Related Videos

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

8.3K
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.6K

Related Experiment Videos

Last Updated: Mar 3, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

10.1K
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

8.3K
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.6K

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Nonsystemic vasculitic neuropathy (NSVN) is an under-recognized peripheral nerve vasculitis.
  • Previous guidelines and diagnostic criteria exist, necessitating an updated review.
  • NSVN diagnosis requires nerve biopsy and can be confused with systemic vasculitis or other neuropathies.

Purpose of the Study:

  • To provide an updated review of the classification, diagnosis, and treatment of NSVN.
  • To propose standardized definitions for NSVN involvement patterns.
  • To offer an updated differential diagnosis for multifocal neuropathy.

Main Methods:

  • Literature review of classification, diagnosis, and treatment of NSVN.
  • Analysis of existing guidelines and diagnostic criteria.
  • Proposal of new definitions for NSVN patterns and differential diagnoses.

Main Results:

  • NSVN has recognized subtypes and variants, with clinical overlap with other vasculitides.
  • Three involvement patterns (multifocal, distal symmetric, overlapping multifocal) lack standard definitions.
  • Combination therapy (corticosteroids + immunosuppressant) may be superior to corticosteroids alone for NSVN and neuropathy-predominant systemic vasculitis.

Conclusions:

  • Updated classification, diagnosis, and treatment strategies for NSVN are presented.
  • Standardized definitions for NSVN patterns are proposed to improve study consistency.
  • While long-term outcomes are generally favorable, NSVN management requires careful consideration of relapse risk and chronic pain.