Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

1.3K
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
1.3K
Energy Balance01:19

Energy Balance

1.3K
The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...
1.3K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

326
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
326
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

3.1K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
3.1K
Regulation of Food Intake01:30

Regulation of Food Intake

3.0K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetic ketoacidosis and hyperosmolar nonketotic state.

Postgraduate medicine·2017
Same author

EFFECTS OF LIRAGLUTIDE 3.0 MG ON WEIGHT AND RISK FACTORS IN HISPANIC VERSUS NON-HIPANIC POPULATIONS: SUBGROUP ANALYSIS FROM SCALE RANDOMIZED TRIALS.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2016
Same author

USE OF METFORMIN IN CLINICAL ENDOCRINOLOGY.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2016
Same author

AACE response to a candid discussion of obesity.

The American journal of medicine·2015
Same author

Bariatric endocrinology: principles of medical practice.

International journal of endocrinology·2014
Same author

Clinical practice guidelines for healthy eating for the prevention and treatment of metabolic and endocrine diseases in adults: cosponsored by the American Association of Clinical Endocrinologists/the American College of Endocrinology and the Obesity Society.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2013
Same journal

Tirzepatide versus conventional GLP-1 receptor agonists for treatment simplification in type 2 diabetes mellitus: a real-world study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Risk-stratification of pediatric thyroid nodules using ATA and ACR TIRADS adult thyroid nodule scoring systems.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Effectiveness of GLP-1 receptor agonists and SGLT-2 inhibitors combination therapy in type 2 diabetes: a real world experience.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

North American Society for Interventional Thyroidology (NASIT) Statement on Directed Ablative Therapy for the Management of of Low Risk Papillary Thyroid Carcinoma.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Lower Cutoffs Improve the Diagnostic Performance of DDAVP-Stimulated Bilateral Inferior Petrosal Sinus Sampling for Cushing Disease: A Prospective Cohort Study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Efficacy of Initiation of Semaglutide versus SGLT2 inhibitors in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Multicenter Propensity-Matched Real-World Study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.8K

BARIATRIC ENDOCRINOLOGY AND VERY-LOW-CALORIE MEAL PLANS.

J Michael Gonzalez-Campoy

    Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
    |April 28, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Protein-sparing modified fast (PSMF) and very-low-calorie meal plans (VLCMP) are effective for weight loss. Both dietary approaches show significant reductions in body weight and improvements in metabolic health markers.

    More Related Videos

    Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
    08:50

    Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

    Published on: October 18, 2024

    1.1K
    Multidisciplinary Approach to Obesity Management: A Case Report
    05:10

    Multidisciplinary Approach to Obesity Management: A Case Report

    Published on: May 30, 2025

    1.4K

    Related Experiment Videos

    Last Updated: Mar 3, 2026

    Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
    10:05

    Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

    Published on: March 20, 2017

    12.8K
    Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
    08:50

    Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

    Published on: October 18, 2024

    1.1K
    Multidisciplinary Approach to Obesity Management: A Case Report
    05:10

    Multidisciplinary Approach to Obesity Management: A Case Report

    Published on: May 30, 2025

    1.4K

    Area of Science:

    • Nutrition science
    • Metabolic health
    • Weight management

    Background:

    • Obesity is a complex global health issue requiring effective dietary interventions.
    • Protein-sparing modified fast (PSMF) and very-low-calorie meal plans (VLCMP) are recognized strategies for rapid weight reduction.
    • Understanding the comparative efficacy and safety of these diets is crucial for clinical practice.

    Purpose of the Study:

    • To compare the effectiveness of PSMF versus VLCMP in achieving weight loss.
    • To assess the impact of both dietary interventions on key metabolic health indicators.
    • To evaluate the safety and tolerability profiles of PSMF and VLCMP.

    Main Methods:

    • A randomized controlled trial design was employed.
    • Participants were assigned to either a PSMF or VLCMP group.
    • Body weight, body composition, and various biochemical markers were monitored over a specified period.

    Main Results:

    • Both PSMF and VLCMP groups demonstrated significant reductions in body weight and body mass index (BMI).
    • Improvements in insulin sensitivity and lipid profiles were observed in both intervention groups.
    • Adverse events were generally mild and comparable between the two diets.

    Conclusions:

    • PSMF and VLCMP are both effective dietary strategies for significant weight loss and metabolic improvements.
    • The choice between PSMF and VLCMP may depend on individual patient factors and clinical goals.
    • Further research should explore long-term adherence and sustainability of these diets.