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Updated: Mar 3, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
IL-33 improves the suppressive potential of regulatory T cells in patients with type 1 diabetes
Monika Ryba-Stanisławowska1, Laura Buksa1, Agnieszka Brandt2
1Department of Immunology, Medical University of Gdańsk, Poland.
Aims:
The presented study was aimed to analyze the influence of IL-33 on regulatory T cells (Tregs) suppressive potential in patients with type 1 diabetes.
Methods:
We analyzed the ability of IL-33 treated Tregs to inhibit the production of IFN-γ by effector T lymphocytes in an in vitro co-culture. The study group consisted of 22 patients with type 1 diabetes and 12 age and sex-matched healthy individuals.
Results:
Our findings revealed that in vitro IL-33 treatment of Tregs derived from patients with type 1 diabetes resulted in quantitative as well as qualitative changes in this cell population, confirming immunoregulatory features of IL-33.
Conclusion:
IL-33 could be considered as a potential therapeutic tool in adoptive therapies of type 1 diabetes.
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