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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Updated: Mar 3, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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Melanoma: a global perspective.

Raul Ossio1, Rodrigo Roldán-Marín2, Héctor Martínez-Said3

  • 1Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Blvd Juriquilla 3001, Santiago de Querétaro 76230, México.

Nature Reviews. Cancer
|April 29, 2017
PubMed
Summary
This summary is machine-generated.

Melanoma research primarily focuses on European populations. Studying melanoma subtypes in diverse ethnic groups is crucial for understanding varied causes and improving treatments for all patients.

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Area of Science:

  • Dermatology and Oncology
  • Genetic Epidemiology

Background:

  • Current melanoma knowledge predominantly stems from European descent populations.
  • Public health initiatives have reduced mortality in these groups.
  • Some melanoma subtypes in non-European populations lack association with ultraviolet (UV) light exposure, indicating different origins.

Purpose of the Study:

  • To investigate melanoma subtypes prevalent in diverse ethnic groups.
  • To understand the distinct risk factors and genomic landscape of these subtypes.
  • To inform tailored therapies and public health strategies for all populations.

Main Methods:

  • Comparative analysis of melanoma subtypes across different ethnicities.
  • Epidemiological studies to identify risk factors.
  • Genomic sequencing to explore the genetic architecture.

Main Results:

  • Identification of melanoma subtypes with non-UV-related etiologies in specific ethnic groups.
  • Preliminary data suggesting distinct genetic profiles for these subtypes.

Conclusions:

  • Melanoma aetiology varies significantly across ethnic groups.
  • Further research into non-UV-associated melanoma subtypes is essential.
  • Developing inclusive public health and therapeutic strategies is critical for global melanoma control.