Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

65.7K
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
65.7K
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

19.7K
19.7K
Van der Waals Interactions01:24

Van der Waals Interactions

72.6K
Atoms and molecules interact with each other through intermolecular forces. These electrostatic forces arise from attractive or repulsive interactions between particles with permanent, partial, or temporary charges. The intermolecular forces between neutral atoms and molecules are ion–dipole, dipole–dipole, and dispersion forces, collectively known as van der Waals forces.
72.6K
Theory of Strong Electrolytes01:23

Theory of Strong Electrolytes

17
The interionic forces of the strong electrolytes depend on the solvent's dielectric constant, which is the ability of a solvent to store electrical energy, based on its polarizability. and the solution's concentration. In high-dielectric solvents and in dilute solutions, weak electrostatic forces keep ions apart. However, in low-dielectric solvents or concentrated solutions, stronger interionic forces may cause ions to pair up as ionic doublets despite being fully ionized. The theory of strong...
17
Induced Electric Dipoles01:28

Induced Electric Dipoles

4.9K
A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
4.9K
Intermolecular Forces03:13

Intermolecular Forces

74.5K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
74.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amine-Enabled Electron Donor-Acceptor Complex Catalysis for Cyclopropanation.

Organic letters·2026
Same author

Unveiling the n → π* interactions in main-group carbonyl complexes.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

A Dearomative Domino Approach for Stereoselective Construction of Functionalized Bridged [4.3.1] Bicycles.

Organic letters·2026
Same author

NHC-Based Diazo Compounds: Pathways to N<sub>2</sub> Liberation or Dimerization.

The Journal of organic chemistry·2026
Same author

Magnesium-Ligand Cooperation Enables Regioselective Transfer Hydrogenation of Quinolines to 1,2-Dihydroquinolines.

Organic letters·2026
Same author

Intramolecular Alder-Ene Reaction of 2-Methyl-4-(alkynyloxy)cyclohexa-2,5-dienones: Catalyst-Free Access to Hydrobenzofuran Derivatives.

Organic letters·2026

Related Experiment Video

Updated: Mar 3, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.8K

Exploiting directional long range secondary forces for regulating electrostatics-dominated noncovalent interactions.

Mrityunjay K Tiwari1, Kumar Vanka1

  • 1Physical and Material Chemistry Division , CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pashan , Pune-411008 , Maharashtra , India .

Chemical Science
|April 29, 2017
PubMed
Summary

This study introduces a quantum chemical method to understand secondary electrostatic interactions (SEIs). This approach enables precise control over the stability and binding energy of supramolecular complexes for rational design.

More Related Videos

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
13:15

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Published on: July 18, 2014

11.5K
Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy
11:34

Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy

Published on: December 20, 2013

7.8K

Related Experiment Videos

Last Updated: Mar 3, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.8K
Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
13:15

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Published on: July 18, 2014

11.5K
Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy
11:34

Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy

Published on: December 20, 2013

7.8K

Area of Science:

  • Supramolecular Chemistry
  • Computational Chemistry
  • Chemical Physics

Background:

  • Long-range secondary electrostatic interactions (SEIs) significantly influence supramolecular complex stability.
  • Developing general rules for utilizing SEIs in rational supramolecular design remains challenging.

Purpose of the Study:

  • To present a quantum chemical methodology for quantifying electrostatic interactions.
  • To demonstrate the application of this method in designing supramolecular complexes with tunable binding affinities.

Main Methods:

  • Utilized quantum chemical calculations to analyze electrostatic forces.
  • Correlated calculated electrostatic forces with experimental binding energies.
  • Applied insights to design novel supramolecular complexes.

Main Results:

  • Established an excellent correlation between electrostatic force and binding energy in hydrogen-bonded and ion-pair complexes.
  • Successfully demonstrated the ability to rationally design complexes with modulated association constants.
  • Showcased a significant increase or decrease in binding affinity by several orders of magnitude.

Conclusions:

  • The developed quantum chemical approach provides a general, simple, and powerful framework for understanding SEIs.
  • This method facilitates the rational design of supramolecular complexes by enabling precise control over electrostatic interactions.
  • Offers a new paradigm for manipulating supramolecular stability and function through secondary electrostatic effects.