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Updated: Apr 8, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Intramolecular Alder-Ene Reaction of 2-Methyl-4-(alkynyloxy)cyclohexa-2,5-dienones: Catalyst-Free Access to
Archana Rai1,2, Priyam Bajpai2,3, Ananya I Kundu1
1Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India.
Abstract:
An atom-economical intramolecular Alder-ene reaction has been developed to construct hydrobenzofurans via the direct coupling of an allylic hydrogen atom to an alkyne. This transformation delivers hydrobenzofuran and hydroindole scaffolds in a single step, incorporating all atoms of the starting materials and exemplifying high atom economy. The synthesized products serve as versatile intermediates and exhibit notable reactivity toward further derivatization, as showcased through a range of transformations enabling rapid access to structurally diverse and complex molecules.
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