Related Experiment Video
Updated: Mar 3, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Perceived need for depression treatment among persons entering inpatient opioid detoxification
Michael D Stein1,2, Olga J Santiago Rivera3, Bradley J Anderson2
1Health Law, Policy & Management, Boston University School of Public Health, Boston, Massachusetts.
Background And Objectives:
Depression is common among persons with opioid use disorder. We examined the perceived need for depression treatment (PNDT) among opioid-dependent patients and the relationship of PNDT to depression screening result.
Methods:
Between May and December 2015, we surveyed consecutive persons (n = 440) seeking inpatient opioid detoxification. We used the Patient Health Questionnaire-2 (PHQ-2) to screen for depression. To assess perceived need for depression services, participants were asked, "Do you believe you should be treated for depression?" Response options were recorded into four categories: "Not Depressed (ND)," "Perceive Need for Depression Treatment (PNDT)," "Depressed/Don't Want Treatment," and "Currently Treated."
Results:
Participants' mean age was 32.3 (±8.7) years; 70.7% were male. Nearly two out of three persons screened positive for depression yet only 8.2% were being treated for depression prior to admission. Screening positive for depression was associated with a 2.95 (95%CI 1.82-4.81, p < .005) fold increase in the expected odds of PNDT. But nearly half of those depressed (48%) did not perceive the need for treatment. Approximately 40% of the participants (n = 177) perceived that they were not depressed; of these persons, 52% screened positive for depression.
Discussion And Conclusions:
Detoxification program staff should screen patients for depression, and if a clinical diagnosis is confirmed, discuss treatment options, exploring the level of interest in mental health treatment for depression.
Scientific Significance:
Screening for and addressing depression, including patients' interest in treatment, should be central to post-detoxification aftercare planning. (Am J Addict 2017;26:395-399).
Related Concept Videos
Drug Dependence
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Depression: Overview
Pharmaceutical Poisoning: Treatment Strategies
CNS Depressants: Barbiturates and Benzodiazepines

