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Primary bone mantle cell lymphomas with multiple vertebral compression fractures: A case report
Peng Yang1, Jun Lin1, Hao Liu1
1Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Oncology Letters
|April 30, 2017
Summary
This study presents a rare case of primary bone Mantle Cell Lymphoma (MCL) in a 75-year-old man, which caused multiple vertebral compression fractures. The diagnosis was confirmed via biopsy and immunohistochemistry, leading to chemotherapy and a positive outcome.
Area of Science:
- Hematology
- Oncology
- Orthopedics
Background:
- Mantle Cell Lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma.
- MCL commonly presents with lymphadenopathy and extranodal involvement.
- Primary bone MCL with vertebral fractures is exceptionally rare.
Purpose of the Study:
- To report a unique case of primary osseous MCL presenting with multiple vertebral compression fractures.
- To highlight the diagnostic challenges and management of this rare condition.
- To contribute to the literature on primary bone lymphomas.
Main Methods:
- Case report of a 75-year-old male with back pain.
- Diagnostic imaging including X-ray, CT, and MRI of the spine.
- Vertebral biopsy with histopathological and immunohistochemical analysis (CD5+, CD20+, cyclin D1+).
- Percutaneous balloon kyphoplasty and subsequent chemotherapy.
Main Results:
- The patient presented with lower back pain and was diagnosed with primary bone MCL.
- Imaging revealed multiple vertebral compression fractures at T10 and L1.
- Histopathology and immunohistochemistry confirmed MCL.
- The patient showed a good clinical condition after 2 months of follow-up.
Conclusions:
- Primary osseous MCL is a rare entity that can manifest with vertebral compression fractures.
- Multimodality imaging and biopsy are crucial for diagnosis.
- Prompt diagnosis and treatment can lead to favorable outcomes in rare MCL presentations.
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