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Amitriptyline-induced supersensitivity of a central muscarinic mechanism: lithium blocks amitriptyline-induced
1Department of Psychiatry and Neuroscience, Ohio State University, Columbus 43210-1228.
Psychiatry Research
|August 1, 1988
Abstract:
Chronic treatment with amitriptyline produces dose-dependent super-sensitivity of a central muscarinic cholinergic mechanism involved in the regulation of core body temperature. The authors demonstrated that chronic treatment with lithium prevents the induction of this response. The potential clinical and theoretical significance of this finding is set forth.