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Testosterone Deficiency and Nocturia: A Review.

Kazuyoshi Shigehara1, Koji Izumi2, Atsushi Mizokami2

  • 1Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. kshigehara0415@yahoo.co.jp.

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Nocturia, linked to testosterone deficiency, may improve with testosterone replacement therapy (TRT). TRT offers a potential alternative treatment for hypogonadal men experiencing nocturia and sleep disturbances.

Keywords:
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Area of Science:

  • Urology
  • Endocrinology
  • Sleep Medicine

Background:

  • Nocturia significantly impacts well-being, causing sleep loss and daytime somnolence.
  • Nocturia is associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders.
  • Testosterone deficiency in elderly men is linked to LUTS, with potential ameliorative effects of testosterone on nocturia.

Purpose of the Study:

  • To explore the relationship between nocturia and testosterone deficiency.
  • To investigate testosterone replacement therapy (TRT) as a potential treatment for nocturia in hypogonadal men.

Main Methods:

  • Review of existing literature on nocturia, LUTS, and testosterone deficiency.
  • Analysis of studies investigating the effects of TRT on nocturia.

Main Results:

  • A negative feedback cycle may exist where testosterone deficiency worsens nocturia, and nocturia further lowers testosterone levels.
  • Current nocturia treatments include fluid restriction and medications like alpha-1 blockers, anticholinergics, and desmopressin.
  • TRT is a recognized treatment for hypogonadism but its specific effects on nocturia require further investigation.

Conclusions:

  • Nocturia negatively affects quality of life and should be appropriately treated.
  • TRT presents a potential alternative treatment for nocturia in hypogonadal men.
  • Further research is necessary to establish definitive conclusions on TRT's efficacy for nocturia.