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High-Throughput Automation in Chemical Process Development
Joshua A Selekman1, Jun Qiu1, Kristy Tran1
1Chemical and Synthetic Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903; email: joshua.selekman@bms.com , jun.qiu@bms.com , kristy.tran@bms.com , jason.stevens@bms.com , victor.rosso@bms.com , eric.simmons@bms.com , yi.xiao@bms.com , jacob.janey@bms.com.
High-throughput (HT) technologies accelerate chemical process development using laboratory automation and statistical design. This review covers HT automation
Area of Science:
- Chemical Engineering
- Process Development
- Laboratory Automation
Background:
- High-throughput (HT) techniques leverage laboratory automation for accelerated chemical process development.
- These methods interrogate vast experimental spaces for optimizing chemical engineering unit operations.
Purpose of the Study:
- To review the evolution of HT technology.
- To provide a comprehensive overview of HT automation in various industries, focusing on chemical and pharmaceutical sectors.
- To highlight strategies for integrating HT automation into routine development.
Main Methods:
- Literature review of HT technology evolution.
- Analysis of HT automation applications in chemical and pharmaceutical process development.
- Identification of common integration strategies for routine development.
Main Results:
- HT technologies have significantly accelerated chemical process development.
- HT automation is widely applied across industries for process design and optimization.
- Effective integration strategies maximize the impact of HT automation in academic and industrial settings.
Conclusions:
- HT automation is a key enabler for efficient chemical and pharmaceutical process development.
- Understanding the evolution and application of HT technologies is crucial for maximizing their benefits.
- Strategic implementation of HT automation enhances routine development activities.
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