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Routes of Drug Administration: Parenteral

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...

One-Compartment Model: IV Infusion

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

One-Compartment Open Model for IV Bolus Administration: General Considerations

One-Compartment Open Model for IV Bolus Administration: General Considerations

The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...

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Related Experiment Video

Updated: Mar 3, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

[IV drug perfusions: safety principles].

Florence Lelieur¹, Delphine Cabelguenne¹, Marie Marcel²

¹Service de pharmacie Groupement hospitalier Sud, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69495 Pierre Bénite Cedex, France.

Revue De L'Infirmiere

|May 3, 2017

Summary

This summary is machine-generated.

Intravenous perfusion procedures carry infection and medication risks. Caregivers must follow best practices for medical device and drug management to ensure patient safety.

Keywords:

gestion des risques intraveineux intravenous medicine médicament perfusion risk management

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Area of Science:

Medical Procedures
Patient Safety
Infection Control

Background:

Intravenous (IV) perfusion is a common medical procedure.
IV perfusions carry inherent risks, including infection and adverse medication events.
Effective risk management is crucial for patient safety during IV therapy.

Purpose of the Study:

To outline the essential best practices for managing risks associated with intravenous perfusion.
To emphasize the importance of proper medical device and drug management in preventing complications.

Main Methods:

Review of established protocols and guidelines for intravenous therapy.
Analysis of common risks and failure modes in IV perfusion.
Synthesis of best practices for healthcare providers.

Main Results:

Adherence to hygiene protocols is fundamental.
Specific best practices are required for the correct use and management of medical devices.
Careful administration and monitoring of drugs are essential to mitigate medication-related risks.

Conclusions:

Implementing comprehensive best practices significantly reduces infection and medication risks during IV perfusion.
Caregiver diligence in device and drug management is paramount for safe patient care.
Standardizing these practices enhances overall patient safety in healthcare settings.