Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

57.9K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.9K
Effects of feedback01:24

Effects of feedback

1.1K
Feedback in control systems plays a critical role in shaping various operational parameters, extending beyond simple error reduction to influence stability, bandwidth, gain, impedance, and sensitivity. Understanding these effects requires examining a basic feedback system characterized by defined input, output, error, and feedback signals.
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...
1.1K
Neural Circuits01:25

Neural Circuits

3.0K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.0K
Design Example: Frog Muscle Response01:14

Design Example: Frog Muscle Response

636
A student is tasked to work on an intriguing experiment involving an RL (Resistor-Inductor) circuit to study the muscle response of a frog's leg to electrical stimulation. The RL circuit plays a crucial role in this experiment, providing the means to control and measure the electrical impulses that trigger muscle contraction.
When the switch connecting the RL circuit is closed, a brief muscle contraction is observed. This is because, at a steady state, the inductor acts like a short...
636
Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

7.5K
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ASTN2 in ASD and neurodevelopmental disorders.

Current topics in developmental biology·2026
Same author

Consensus Paper: Models of Cerebellar Functions.

Cerebellum (London, England)·2026
Same author

Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.

Current biology : CB·2025
Same author

A deep learning strategy to identify cell types across species from high-density extracellular recordings.

Cell·2025
Same author

Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients.

Science translational medicine·2024
Same author

Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Mar 3, 2026

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

9.8K

Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.

Court Hull1

  • 1Department of Neurobiology, Duke University, Durham, North Carolina 27710 Hull@neuro.duke.edu.

Cold Spring Harbor Protocols
|May 3, 2017
PubMed
Summary

This study details methods to measure feedforward inhibition in cerebellar brain slices. Researchers explored how this neural circuit impacts Purkinje cell activity and precise spike timing.

More Related Videos

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
09:50

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation

Published on: October 6, 2011

17.8K
Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

10.4K

Related Experiment Videos

Last Updated: Mar 3, 2026

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

9.8K
Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
09:50

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation

Published on: October 6, 2011

17.8K
Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

10.4K

Area of Science:

  • Neuroscience
  • Cellular Neuroscience
  • Circuit Neuroscience

Background:

  • The cerebellum plays a crucial role in motor control and learning.
  • Understanding neural circuit function, particularly inhibitory mechanisms, is vital for comprehending cerebellar processing.
  • Feedforward inhibition is a key circuit motif that regulates neuronal activity.

Purpose of the Study:

  • To describe a detailed protocol for measuring feedforward inhibition in the cerebellar cortex.
  • To quantify the relationship between excitation and inhibition within a feedforward circuit.
  • To assess the influence of feedforward inhibition on Purkinje cell excitability and spike timing.

Main Methods:

  • Utilizing acute brain slices from the cerebellar cortex.
  • Employing whole-cell voltage and current clamp recordings from Purkinje cells.
  • Performing electrical stimulation of parallel fibers to activate the feedforward circuit.

Main Results:

  • Established methods to measure the excitation-inhibition balance in cerebellar circuits.
  • Quantified the impact of feedforward inhibition on Purkinje cell excitability.
  • Demonstrated the influence of feedforward inhibition on action potential timing.

Conclusions:

  • The described protocol provides a robust framework for studying feedforward inhibition in the cerebellum.
  • Accurate measurement of feedforward inhibition is essential for understanding Purkinje cell function.
  • This work contributes to the broader understanding of cerebellar circuit dynamics and information processing.