Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial: How Will Aducanumab Approval Impact AD Research?

The journal of prevention of Alzheimer's disease·2021

Same author

Signal Hyperintensity on Unenhanced T1-Weighted Brain and Cervical Spinal Cord MR Images after Multiple Doses of Linear Gadolinium-Based Contrast Agent.

AJNR. American journal of neuroradiology·2019

Same author

Toward Precision and Reproducibility of Diffusion Tensor Imaging: A Multicenter Diffusion Phantom and Traveling Volunteer Study.

AJNR. American journal of neuroradiology·2016

Same author

Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline.

AJNR. American journal of neuroradiology·2015

Same author

FASTKD2 is associated with memory and hippocampal structure in older adults.

Molecular psychiatry·2014

Same author

Physical activity, inflammation, and volume of the aging brain.

Neuroscience·2014

Same journal

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.

Molecular psychiatry·2026

Same journal

Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy.

Molecular psychiatry·2026

Same journal

Subtyping OCD based on individual symptom networks: subtype-specific neural dynamics and morphometric similarity linked to molecular profiles.

Molecular psychiatry·2026

Same journal

Atrophy in preclinical Alzheimer's disease maps to a network that predicts longitudinal decline.

Molecular psychiatry·2026

Same journal

Towards modelling mental disorders in zebrafish. Neurexins severely modulate anxiety, affiliative social behaviour and aggression.

Molecular psychiatry·2026

Same journal

Targeting cortico-striatal-amygdalar networks via theta-band frontoparietal synchronization in opioid use disorder: a randomized tACS-fMRI Trial.

Molecular psychiatry·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 3, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Connectome imaging for mapping human brain pathways.

Y Shi¹, A W Toga¹

¹Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Molecular Psychiatry

|May 3, 2017

Summary

This summary is machine-generated.

Advanced diffusion MRI techniques enable high-resolution mapping of human brain pathways. This review covers diffusion MRI developments, fiber orientation distribution models, and tractography for connectome studies.

More Related Videos

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

Related Experiment Videos

Last Updated: Mar 3, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

Area of Science:

Neuroimaging
Neuroscience
Medical Physics

Background:

Diffusion magnetic resonance imaging (MRI) is rapidly advancing, offering unprecedented resolution for mapping human brain pathways in vivo.
The Human Connectome Project utilizes state-of-the-art multi-shell acquisition schemes, presenting both technical advances and challenges.

Purpose of the Study:

To review current developments in diffusion MRI for reconstructing anatomical pathways in connectome studies.
To discuss microstructural characterization from tensor to fiber orientation distribution (FOD) models.
To highlight novel methods for fiber bundle reconstruction and connectivity analysis using FOD-based tractography.

Main Methods:

Review of diffusion MRI techniques, including multi-shell acquisition.
Discussion of microstructural modeling: tensor models and fiber orientation distribution (FOD) models.
Application of FOD-based tractography for fiber bundle reconstruction and graph-based connectivity analysis.

Main Results:

Fiber orientation distribution (FOD) models can resolve crossing fibers within each image voxel.
Novel methods enable successful reconstruction of challenging brain pathways, such as retinofugal and brainstem pathways.
Demonstrated applications of connectome imaging techniques in detailed pathway mapping.

Conclusions:

Diffusion MRI, particularly with FOD-based tractography, is a powerful tool for in vivo human connectome studies.
Continued advancements in imaging and analysis methods promise further insights into brain connectivity.
Future directions involve integrating connectome imaging with other brain imaging research areas.