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Targeted Radionuclide Therapy: An Evolution Toward Precision Cancer Treatment

Hossein Jadvar1

  • 11 Department of Radiology, Division of Nuclear Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar St, CSC Ste 102, Los Angeles, CA 90033.

AJR. American Journal of Roentgenology
|May 3, 2017
PubMed
Abstract

Insights

Targeted radionuclide therapy (TRT) offers new hope for treating liver lesions, bone metastases, neuroendocrine tumors, and prostate cancer. Advances in theranostics and precision medicine are driving a resurgence in this established cancer treatment.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Targeted radionuclide therapy (TRT) has a long history, dating back to early radioiodine treatments.
  • Recent progress in cancer biology and radiochemistry has revitalized TRT.
  • The integration of multimodal imaging and theranostics is key to TRT's advancement.

Purpose of the Study:

  • To review recent developments in targeted radionuclide therapy (TRT).
  • To focus on TRT applications for malignant liver lesions, bone metastases, neuroendocrine tumors, and castrate-resistant metastatic prostate cancer.
  • To discuss current challenges and future opportunities in the field of TRT.

Main Methods:

  • Literature review of recent advancements in TRT.
  • Analysis of TRT applications in specific cancer types.
  • Discussion of challenges and opportunities based on current research and clinical practice.

Main Results:

  • TRT is being increasingly applied to various metastatic cancers.
  • Theranostics, combining "see and treat" approaches, enhance TRT efficacy.
  • Precision medicine principles are guiding the development of new TRT strategies.

Conclusions:

  • TRT has experienced a resurgence due to scientific and technological progress.
  • Advances in understanding cancer biology and radiochemistry are crucial.
  • The synergy of theranostics and precision medicine positions TRT as a vital tool in modern oncology.
Keywords:
cancerprecisionradionuclidetherapy

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