Triterpenoids with antioxidant activities from Myricaria squamosa
Heng Xu1,2, Zhen-Zhen Yuan1,2, Xiao Ma1,2
1a Key Laboratory of Tibetan Medicine Research , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xining 810008 , China.
Journal of Asian Natural Products Research
|May 3, 2017
Summary
Researchers isolated a new triterpenoid, myricarin C, and three known compounds from Myricaria squamosa. Myricarin A and myricarin C demonstrated antioxidant properties, while myricarin B showed weaker activity, and compound 4 was inactive.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Medicinal Chemistry
Background:
- Myricaria squamosa is a plant species with potential medicinal properties.
- Triterpenoids are a class of natural compounds with diverse biological activities.
Purpose of the Study:
- To isolate and characterize compounds from the overground parts of Myricaria squamosa.
- To evaluate the antioxidant properties of the isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via 1D-NMR, 2D-NMR, and HR-ESI-MS.
- Assessment of antioxidant activity using DPPH radical scavenging assay.
Main Results:
- A new triterpenoid, myricarin C, was identified along with known compounds myricarin A, myricarin B, and 3α-hydroxy-D-friedoolean-14-en-28-oic acid.
- Myricarin A and myricarin C exhibited notable antioxidant activities (EC50 values of 40.90 μg/ml and 42.22 μg/ml, respectively).
- Myricarin B showed moderate antioxidant activity (EC50 = 195.81 μg/ml), while compound 4 was inactive.
Conclusions:
- Myricaria squamosa is a source of bioactive triterpenoids.
- Myricarin A and myricarin C possess significant antioxidant potential.
- Further research into these compounds may lead to the development of new antioxidant agents.
