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Protein kinase C activators inhibit the antigen receptor-coupled polyphosphoinositide phosphodiesterase in murine B
1Division of Immunology, National Institute for Medical Research, London, England.
FEBS Letters
|November 7, 1988
Abstract:
Protein kinase C activators (e.g. PMA) inhibit the inositol phosphate release generated by crosslinking antigen receptors (sIgM and sIgD) on murine B lymphocytes with anti-receptor antibodies. Unlike other Ca2+-mobilizing receptor systems, the antigen receptor signal transduction pathway in B cells is not interrupted by PMA at the level of receptor/G-protein or G-protein/polyphosphoinositide phosphodiesterase coupling. In these cells, PMA, presumably by activating protein kinase C, inhibits inositol phosphate release by direct effects on the polyphosphoinositide-specific phosphodiesterase.