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Updated: Mar 3, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
A Case of Exertional Rhabdomyolysis: When Exertion Exceeds Capacity
Kathleen S Jordan1, Sarah E Mannle
1Mid-Atlantic Emergency Medicine Associates, Charlotte, North Carolina (Dr Jordan); School of Nursing, The University of North Carolina at Charlotte (Dr Jordan); and Western Carolina University and Haywood Regional Hospital, Clyde, North Carolina (Dr Mannle).
Abstract:
The purpose of this article is to present a discussion of a young adult patient with exertional rhabdomyolysis. Rhabdomyolysis is the process of muscle tissue destruction and damage to the cell membrane, with subsequent release of the intracellular myocyte contents into the systemic circulation. This leads to the potential for the life-threatening systemic complications of electrolyte abnormalities, cardiac dysrhythmias, acute kidney injury, compartment syndrome, and disseminated intravascular coagulopathy. Rhabdomyolysis as a syndrome can be difficult to recognize and diagnose in the emergency care setting due to the fact that there are many etiologies and variations in symptomatology. The emergency care provider must have an astute knowledge base of this disease process and consider this pathology in the differential diagnosis of any patient at risk to achieve optimum patient outcomes and reduce morbidity and mortality.
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