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Primary Ovarian Solid Pseudopapillary Neoplasm With CTNNB1 c.98C>G (p.S33C) Point Mutation
Kamaljeet Singh1, Nimesh Patel, Pallavi Patil
1Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Women & Infants Hospital of Rhode Island (K.S., C.P., W.D.L.) Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Rhode Island Hospital (N.P., P.P.) Program in Women's Oncology, Women & Infants Hospital (C.A.M.), Providence, Rhode Island.
Abstract:
Ovary is one of the extrapancreatic sites of origin of solid pseudopapillary neoplasm (SPN). Only 9 cases of primary ovarian SPN, 1 with CTNNB1 mutation similar to pancreatic SPN, have been reported in the English literature. We describe the second case of ovarian SPN with confirmed CTNNB1 mutation. A 49-year-old postmenopausal woman presented with a 4.5 cm right ovarian mass. Ovarian mass showed histologic and immunohistochemical features of pancreatic SPN. The ovarian surface was intact and uninvolved. Ki-67 index was low (1%-5%). DNA sequencing of CTNNB1 exon 3 revealed c.98C>G (p.S33C), a well-characterized activating mutation. Our case adds to the growing body of evidence that primary ovarian SPN are phenotypically and genotypically similar to pancreatic SPN.
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