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Rational Combination Immunotherapy: Understand the Biology
1Departments of Surgery and Medicine, Rutgers University, New Brunswick, New Jersey. howard.kaufman@rutgers.edu.
Abstract:
Selecting rational treatment combinations remains a major challenge for improving immunotherapy outcomes. In this issue of Cancer Immunology Research, Zhang and colleagues reduced tumors by inhibiting CD47 in a lung carcinoma model, a treatment that inadvertently induced autophagy through inhibition of the Akt/mTOR pathway. By also targeting autophagy, the therapeutic response improved, highlighting the importance of understanding the biology beneath antitumor immunity. Cancer Immunol Res; 5(5); 355-6. ©2017 AACRSee article by Zhang et al., p. 363.
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