Polymorphism of ERK/PTPRR Genes in Major Depressive Disorder at Resting-State Brain Function
Yanfang Wang1, Lusha Li1, Cheng Xu2
1a Department of Psychiatry , First Hospital of Shanxi Medical University , Taiyuan , People's Republic of China.
Abstract:
The polymorphism of ERK and PTPRR in MDD is rarely reported. The present study investigated the association between the polymorphism of ERK/PTPRR and MDD at resting-state brain function using genomic imaging. It indicated that the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) in functional magnetic resonance imaging (fMRI) changed significantly in various brain regions of MDD patients. The T/G allele of ERK-rs1267842 and G/C allele of PTPRR-rs1513105 showed abnormal ALFF and ReHo changes in cortex including superior frontal gyrus and middle temporal gyrus. The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105.
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