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Updated: Mar 3, 2026
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Latent Tuberculosis Infection Testing Practices in Long-Term Care Facilities, Boston, Massachusetts
Divya Reddy1, Jacob Walker2, Laura F White3
1Section of Pulmonary, Allergy, Sleep and Critical Care, Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts.
Objectives:
To describe latent tuberculosis infection (LTBI) testing practices in long-term care facilities (LTCFs).
Design:
Retrospective cohort study.
Setting:
Three Boston-area LTCFs.
Participants:
Residents admitted between January 1 and December 31, 2011.
Measurements:
Resident demographic characteristics, comorbidities, LTCF stay, and LTBI testing and treatment.
Results:
Data for 291 LTCF residents admitted in 2011 were reviewed. Of the 257 without a history of LTBI and with documentation of testing, 162 (63%) were tested; 114 of 186 (61%) with a stay less than 90 days and 48 of 71 (68%) with a stay of 90 days or longer were tested. Of 196 residents with data on prior LTBI testing, 39 (19.9%) had LTBI; 12 of these (30.8%) were diagnosed at the LTCF. Hispanic participants were more likely than black participants to undergo LTBI testing (adjusted odds ratio (aOR) = 2.4, P = .003). Having a length of stay of less than 90 days (aOR = 0.7, P < .001) and history of illicit drug use (aOR = 0.7, P < .001) were associated with lower odds of LTBI testing.
Conclusion:
One-fifth of LTCF residents had LTBI, but testing was not always performed. The high prevalence of LTBI in older adults combined with the risk of an outbreak if a case of tuberculosis occurs in a LTCF make LTBI testing and treatment an important prevention opportunity. The importance of LTBI testing in LTCFs needs to be reinforced.
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