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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Corrigendum to "Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress" [Toxicology 361-362 (2016) 39-48].

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What Makes Cirrhosis Irreversible?-Consideration on Structural Changes.

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miR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver.

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Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes-Associated Protein 1 Activation and Transient Expansion of Stem-Like Cancer Cells.

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Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.

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c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition and Regulates Cell Phenotypic Switch.

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Related Experiment Video

Updated: Mar 3, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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Stemness in Liver Cancer.

Snorri S Thorgeirsson1

  • 1Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.

Digestive Diseases (Basel, Switzerland)
|May 4, 2017
PubMed
Summary

Cancer stem cells (CSCs) drive tumor growth and relapse. In liver cancer, CSCs with stem-cell properties are linked to poor prognosis, but reprogramming pathways offer potential therapeutic targets.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Hepatocellular Carcinoma Research

Background:

  • Cancer stem cells (CSCs) possess stem-cell properties and are crucial for tumor initiation, propagation, and therapeutic relapse.
  • CSCs represent a significant challenge in cancer research due to their role at the apex of the cancer hierarchy.
  • Hepatocellular carcinomas with stem cell features are associated with poor prognosis and therapeutic resistance.

Purpose of the Study:

  • To investigate the oncogenic reprogramming of normal cells into CSCs within the mouse hepatic lineage.
  • To identify common and cell-of-origin-specific molecular changes during CSC formation.
  • To explore potential therapeutic targets for liver cancer based on CSC characteristics.

Main Methods:

  • Investigated oncogenic reprogramming of mouse hepatic lineage cells into CSCs.
Keywords:
CancerCancer stem cellsLiverStemness

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  • Activated cell type-specific pathways to induce CSC phenotypes.
  • Analyzed phenotypic and genetic alterations in reprogrammed cells.

    • Main Results:

    • Demonstrated that any cell type in the mouse hepatic lineage can be reprogrammed into a CSC.
    • Identified that specific cell type-specific pathways mediate this oncogenic transformation.
    • Highlighted the potential for identifying common and origin-specific changes.

    Conclusions:

    • Liver cancer cells with stemness properties are a distinct subclass with poor prognosis.
    • Oncogenic reprogramming of hepatic cells into CSCs is achievable through specific pathways.
    • Identifying CSC-specific molecular changes can lead to novel therapeutic strategies for liver cancer.