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Measuring Gene Expression in Bombarded Barley Aleurone Layers with Increased Throughput

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Abscisic Acid as Pathogen Effector and Immune Regulator.

Laurens Lievens^1,2, Jacob Pollier^3,4, Alain Goossens^3,4

¹Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, VIBGhent, Belgium.

Frontiers in Plant Science

|May 5, 2017

Summary

Abscisic acid (ABA), a plant hormone, also impacts animal health by reducing inflammation and metabolic issues. Further research into ABA

Keywords:

comparative biology host-microbe interactions immunity inflammation metabolic engineering natural product chemistry signal transduction systems biology

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Area of Science:

Biochemistry
Molecular Biology
Immunology

Background:

Abscisic acid (ABA) is a vital plant hormone regulating abiotic stress responses.
ABA is conserved across life, acting as a signaling molecule in inter-species communication.
Emerging evidence suggests ABA's therapeutic potential in human inflammatory diseases.

Purpose of the Study:

To explore the conserved roles and potential applications of Abscisic acid (ABA).
To highlight ABA's function beyond plant stress resistance, including in host-pathogen and mutualistic interactions.
To investigate ABA's therapeutic potential in human health.

Main Methods:

Literature review of ABA's functions across different kingdoms.
Analysis of ABA's role in plant stress, immunity, and inter-species communication.
Examination of ABA's effects on human inflammatory diseases and metabolic reprogramming.

Main Results:

ABA suppresses host immunity and is used by pathogens as an effector molecule.
ABA mediates plant-microbe interactions in mycorrhiza and rhizosphere.
ABA demonstrates anti-inflammatory effects beneficial for colitis and type 2 diabetes in humans.

Conclusions:

ABA's conserved signaling functions suggest its broad biological importance.
ABA holds promise as a nutraceutical or pharmacognostic agent for inflammatory conditions.
Leveraging plant science knowledge can advance understanding of endogenous ABA in human health.