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Zoledronic acid for neonatal subcutaneous fat necrosis
Jeremy A Di Bari1, Jennifer A Nead2, Scott J Schurman3
1Resident, Family MedicineSt. Joseph's Hospital Health Center 301 Prospect Ave Syracuse New York 13203 USA.
Subcutaneous fat necrosis in infants causing severe hypercalcemia is a critical emergency. Treatment with prednisolone and zoledronic acid effectively normalized calcium levels without complications.
Area of Science:
- Neonatal medicine
- Pediatric endocrinology
- Dermatology
Background:
- Subcutaneous fat necrosis (SFN) in infants can lead to life-threatening hypercalcemia.
- Pathophysiology involves increased intestinal calcium absorption and bone resorption.
Observation:
- A case of infant SFN with severe hypercalcemia (serum calcium 15 mg/dL) was observed.
- The infant was treated with prednisolone and low-dose zoledronic acid.
Findings:
- Serum calcium levels promptly normalized after treatment.
- No rebound hypocalcemia or need for redosing of zoledronic acid was observed.
Implications:
- This treatment approach offers a potential strategy for managing hypercalcemia in SFN.
- Early intervention may prevent severe complications associated with hypercalcemia in infants.
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