Central nervous system involvement of acute promyelocytic leukemia, three case reports
Aya Furuya1, Masahiro Kawahara1, Mina Kumode1
1Division of Gastroenterology and Hematology Department of Medicine Shiga University of Medical Science Otsu Japan.
Abstract:
Central nervous system (CNS) involvement of acute promyelocytic leukemia (APL) causes poor prognosis. Our three cases show that CNS can be involved at the first hematological recurrence, but predicting this is difficult. Triple intrathecal treatment and craniospinal irradiation were effective, while arsenic oxide failed to prevent and improve CNS involvement.
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