Rationally Designed Solvatochromic Fluorescent Indoline Derivatives for Probing Mitochondrial Environment
Kaushik Pal1, Apurba Lal Koner1
1Department of Chemistry, Indian Institution of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal-, 462066, India.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 5, 2017
Abstract:
A new class of solvatochromic, robust, and multifunctional fluorescent probes derived from indoline is presented. Specificity of mitochondria targeting was achieved and utilized for probing polarity under normal and apoptotic conditions. A large Stokes shift, high quantum yield, thermal, photochemical, and pH stability, tolerance to buffer compositions, and a bioconjugation tool-kit make it a promising candidate for live-cell fluorescence imaging.
