Using CorvisST tonometry to assess glaucoma progression

Area of Science:

• Ophthalmology
• Medical Technology
• Glaucoma Research

Background:

• Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
• Accurate assessment of visual field (VF) damage progression is crucial for managing glaucoma.
• Existing methods may benefit from advanced imaging technologies for improved diagnostic capabilities.

Purpose of the Study:

• To evaluate the effectiveness of Corneal Visualization Scheimpflug Technology (CST) in monitoring VF progression in POAG patients.
• To determine the association between CST parameters and the rate of VF damage progression.
• To identify specific CST metrics that indicate a higher risk of glaucoma progression.

Main Methods:

• A cohort of 75 eyes from 111 POAG patients was studied.
• Patients underwent multiple VF tests (Humphrey Field Analyzer), CST measurements, axial length (AL), central corneal thickness (CCT), and intraocular pressure (IOP) assessments.
• Linear regression analysis was used to model the mean total deviation (mTD) progression rate against various ocular parameters, with model selection based on AICc.

Main Results:

• VF progression was best explained by a model incorporating CST parameters and other ocular measurements.
• The optimal linear model for mTD progression rate included mean Goldmann applanation tonometry (GAT) IOP, CST parameters (A1 time, A2 time, A2 length), and highest deformation amplitude.
• Specific CST findings like rapid applanation, wide applanated area, and deep indentation correlated with VF progression.

Conclusions:

• CST measurements are valuable tools for assessing VF progression in glaucoma.
• Certain CST characteristics, such as rapid applanation, wide applanated area, and deep indentation, identify patients at increased risk of VF progression.
• Integrating CST data with traditional ocular measurements can enhance the prediction of glaucoma progression.