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Related Experiment Video

Updated: May 6, 2026

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

Advances in engineering hydrogels.

Yu Shrike Zhang^1,2,3, Ali Khademhosseini^4,2,3,5,6

¹Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

Science (New York, N.Y.)

|May 6, 2017

Summary

This summary is machine-generated.

This review covers advances in engineering hydrogels, focusing on improving their mechanical strength and functionality. Strategies include innovative chemistries, dynamic modulation, and sophisticated architectures for diverse applications.

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Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

Area of Science:

Materials Science
Polymer Chemistry
Biomedical Engineering

Background:

Hydrogels, composed of hydrophilic polymer chains in a water-rich environment, are widely used in biomedicine, soft electronics, sensors, and actuators.
Conventional hydrogels suffer from limited mechanical strength and susceptibility to permanent breakage.
Existing hydrogels often lack dynamic cues and structural complexity, restricting their functional capabilities.

Purpose of the Study:

To review recent advancements in the design and engineering of hydrogels.
To highlight strategies for precise manipulation of hydrogel properties across multiple scales.
To address limitations of conventional hydrogels, focusing on mechanical strength and dynamic functionality.

Main Methods:

Review of innovative chemistries and compositions for hydrogel development.
Integration of dynamic modulation techniques in hydrogel design.
Exploration of sophisticated architectures for enhanced hydrogel performance.

Main Results:

Engineered hydrogels exhibit improved physicochemical properties compared to conventional ones.
New designs enhance mechanical strength, reduce susceptibility to breakage, and introduce dynamic responsiveness.
Advanced architectures contribute to increased structural complexity and tailored functionalities.

Conclusions:

Significant progress has been made in engineering hydrogels with superior properties.
Strategies involving chemistry, dynamic modulation, and architecture are key to overcoming limitations.
These engineered hydrogels offer expanded potential for advanced applications in various fields.