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The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm

Magdalena Budzyń1, Bogna Gryszczyńska1, Wacław Majewski2

  • 1Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Poznań University of Medical Sciences, Poznań, Poland.

Biomed Research International
|May 6, 2017
PubMed

Insights

Serum thrombomodulin (sTM) is elevated in patients with abdominal aortic aneurysm (AAA), indicating endothelial damage. This elevation correlates with lipids, inflammation, and oxidative stress.

Area of Science:

  • Vascular Biology
  • Biomarkers
  • Endothelial Dysfunction

Background:

  • Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by aortic wall weakening.
  • Endothelial injury is implicated in the pathogenesis of AAA.
  • Serum thrombomodulin (sTM) is a marker of endothelial activation and damage.

Purpose of the Study:

  • To measure serum thrombomodulin (sTM) levels in patients with AAA.
  • To investigate the correlation between sTM concentration and factors contributing to endothelial injury in AAA.

Main Methods:

  • Enzyme-linked-immunosorbent assay (ELISA) was used to quantify sTM.
  • AAA patients (n=41) were compared to healthy controls (n=30).
  • Subgroup analyses were performed based on various criteria.

Main Results:

  • AAA patients exhibited significantly higher sTM concentrations than controls (3.93 ng/mL vs. 2.37 ng/mL, P < 0.001).
  • Elevated sTM levels were significantly associated with increased triglycerides, cholesterol, hsCRP, and advanced glycation end products (AGEs).

Conclusions:

  • Increased serum sTM suggests endothelial damage is a key component of AAA pathogenesis.
  • Lipid abnormalities, inflammation, and oxidative stress are implicated in the destructive process of AAA.

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