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Updated: Mar 3, 2026
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Identifying Protein-protein Interaction Sites Using Peptide Arrays
Published on: November 18, 2014
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Peptide array functionalization via the Ugi four-component reaction
B Ridder1, D S Mattes, A Nesterov-Mueller
1Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany. frank.breitling@kit.edu.
Chemical Communications (Cambridge, England)
|May 6, 2017
Abstract:
The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi unit into a growing peptide chain was demonstrated.
