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Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve.

Bowei Li1, Lijuan Yu2, Ji Qi3

  • 1Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , Yantai 264003, China.

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Researchers developed a novel movable valve for paper-based microfluidic devices using hollow rivets. This user-friendly innovation enables precise fluid control for complex multistep operations and point-of-care diagnostics.

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Area of Science:

  • Microfluidics
  • Analytical Chemistry
  • Materials Science

Background:

  • Paper-based microfluidic devices (μPADs) offer low-cost platforms for diagnostics.
  • Controlling fluid flow in μPADs is crucial for multistep assays.
  • Existing valve mechanisms can be complex or require precise timing.

Purpose of the Study:

  • To introduce a novel, user-friendly movable valve for manipulating capillary-driven fluids in μPADs.
  • To demonstrate the valve's robustness, versatility, and compatibility with complex μPAD designs.
  • To validate the valve's performance in diagnostic assays.

Main Methods:

  • Fabrication of movable valves using hollow rivets as central anchors.
  • Integration of valves into various μPAD designs to control channel connectivity.
  • Testing valve performance in proof-of-concept enzyme-linked immunosorbent assay (ELISA) for carcino-embryonic antigen detection.

Main Results:

  • Successful fabrication of a simple, robust, and versatile movable valve.
  • Demonstrated precise, timing-free fluid control for connecting/disconnecting paper channels.
  • Achieved sensitive and reproducible detection of carcino-embryonic antigen using the valve-integrated μPADs.

Conclusions:

  • The novel hollow rivet-based movable valve offers an accessible method for fluid control in μPADs.
  • This technique simplifies complex operations, enhancing user-friendliness for untrained individuals.
  • The developed valves show significant potential for point-of-care diagnostic applications.