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NewProt - a protein engineering portal.

Andreas Schwarte1, Maika Genz2, Lilly Skalden2

  • 1Fluid Operations AG, Walldorf, Germany.

Protein Engineering, Design & Selection : PEDS
|May 6, 2017
PubMed
Summary
This summary is machine-generated.

The NewProt portal offers a comprehensive suite of in silico tools for protein engineering, aiding in the modification of protein structures and functions through point mutations. It integrates visualization and specialized software for predicting side effects and designing beneficial mutations.

Keywords:
mutant analysisportalprotein designprotein engineeringweb server

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Area of Science:

  • Protein Engineering
  • Computational Biology
  • Bioinformatics

Background:

  • Protein engineering enables the modification of protein structure and function.
  • In silico methods accelerate the design and analysis of protein modifications.
  • Predicting the effects of mutations is crucial for successful protein engineering.

Purpose of the Study:

  • To introduce the NewProt protein engineering portal as a centralized resource.
  • To provide access to various computational tools for protein structure analysis and modification.
  • To facilitate the design of proteins with altered activity, specificity, or stability.

Main Methods:

  • The NewProt portal integrates multiple bioinformatics servers for calculating protein structure characteristics.
  • It includes visualization tools for inspecting mutation effects.
  • The portal incorporates the HOPE software for predicting undesired mutation side effects.
  • The Hotspot Wizard software is embedded for designing mutations to enhance protein properties.

Main Results:

  • The NewProt portal provides a unified platform for in silico protein engineering.
  • It offers a wide range of computational analyses for protein structure and function.
  • Users can predict potential side effects of mutations and design targeted modifications.
  • The portal supports the introduction of single or multiple point mutations.

Conclusions:

  • The NewProt portal serves as a valuable, freely accessible resource for researchers in protein engineering.
  • It streamlines the process of in silico protein design and modification.
  • The integrated tools empower scientists to engineer proteins with desired characteristics efficiently.