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DNA conformational variations in the in vitro torsionally strained Ig kappa light chain gene localize on consensus
S Venditti1, M Caserta, E Di Mauro
1Dipartimento di Genetica e Biologia Molecolare, Università di Roma La Sapienza, Italy.
Biochimica Et Biophysica Acta
|November 10, 1988
Abstract:
We have analyzed the localization and the dependence upon superhelical density of the DNA sites which modify their conformation under torsional strain in a mouse Ig L kappa gene. The conformational variations occur on DNA sites which have been defined as protein interaction sites and consensus sequence motifs: the 5'-upstream regulatory decanucleotides, the TATA sequence, the consensus heptanucleotides of the J recombinational sequences.