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Beta-adrenergic regulation of c-fos gene expression in an epithelial cell line
C K Yeh1, J M Louis, E E Kousvelari
1Clinical Investigations and Patient Care Branch, National Institute of Dental Research, Bethesda, MD 20892.
FEBS Letters
|November 21, 1988
Abstract:
Stimulation of beta-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.