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Related Experiment Videos

Cytosolic calcium oscillators.

M J Berridge1, A Galione

  • 1Department of Zoology, Cambridge University, UK.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|December 1, 1988
PubMed
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Cellular calcium oscillations, driven by periodic calcium release, are sensitive to stimuli and may encode information via frequency modulation. This signaling mechanism, involving inositol 1,4,5-trisphosphate, is crucial for cellular communication.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Signaling Pathways

Background:

  • Cells exhibit intracellular calcium oscillations due to periodic release from internal stores.
  • Oscillation frequencies vary (5-60s) and are influenced by external factors like stimuli and calcium concentration.
  • Cytosolic calcium oscillators are sensitive to stimuli that hydrolyze phosphoinositides, producing diacylglycerol and inositol 1,4,5-trisphosphate (Ins1,4,5P3).

Purpose of the Study:

  • To explore the mechanisms underlying cellular calcium oscillations.
  • To investigate the role of inositol 1,4,5-trisphosphate (Ins1,4,5P3) in calcium mobilization and oscillatory activity.
  • To understand the potential functional significance of calcium oscillations in cellular signaling.

Main Methods:

  • Review and analysis of proposed models for calcium oscillations.

Related Experiment Videos

  • Examination of receptor-controlled and second messenger-controlled oscillator models.
  • Discussion of calcium-induced calcium release as a potential oscillatory mechanism.

    • Main Results:

    • Inositol 1,4,5-trisphosphate (Ins1,4,5P3) is a key mediator in mobilizing intracellular calcium for oscillatory activity.
    • Oscillator models involve feedback mechanisms regulating Ins1,4,5P3 levels or calcium reservoir release.
    • Calcium-induced calcium release is proposed as a basis for oscillations in various cell types.

    Conclusions:

    • The precise function of calcium oscillations remains to be fully elucidated.
    • Oscillator frequency variation with agonist concentration suggests a role in frequency-encoded signaling.
    • Calcium transients may act as a digitized signal, with frequency variations conveying information about external stimuli.