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Neuroprotection provided by isoflurane pre-conditioning and post-conditioning
Ming Jiang1, Liang Sun1, Dong-Xia Feng2
1Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Medical Gas Research
|May 9, 2017
Summary
Isoflurane, an inhalational anesthetic, shows neuroprotective effects in animal models of brain injury. However, human trial evidence is needed to confirm its clinical use for neurodegenerative diseases.
Area of Science:
- Anesthesiology
- Neuroscience
- Pharmacology
Background:
- Isoflurane is a widely used volatile anesthetic.
- Experimental studies suggest isoflurane has neuroprotective properties.
- Neuroprotection is observed in models of hypoxic ischemia, stroke, and trauma.
Purpose of the Study:
- To review the neuroprotective mechanisms of isoflurane.
- To evaluate the evidence for isoflurane's neuroprotection in human trials.
Main Methods:
- Review of experimental studies on isoflurane's neuroprotective effects.
- Analysis of proposed molecular mechanisms.
- Assessment of human clinical trial data.
Main Results:
- Isoflurane pre-conditioning and post-conditioning demonstrate neuroprotection in various animal models.
- Mechanisms include modulation of glycine and GABA receptors, ion channels, and protein activity.
- Limited human trial data currently exists.
Conclusions:
- Isoflurane exhibits promising neuroprotective potential based on preclinical data.
- Further human clinical trials are essential to validate these findings for therapeutic application.
- Translating isoflurane's neuroprotective benefits to clinical practice requires more robust evidence.
