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Updated: Mar 2, 2026

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
Published on: May 2, 2025
Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases
Xue-Qin Hou1, Lei Wang2, Fu-Gang Wang3
1Institute of Pharmacology, Taishan Medical University, Taian 271016, Shandong, China. houxueqin09@126.com.
Abstract:
RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases.
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