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Intravenous Ceftriaxone for Syphilitic Uveitis.
Fernanda A Agostini1,2, Rafael P Queiroz1,3,4, Danuza O M Azevedo1
1a Uveitis Unit, Hospital São Geraldo / Hospital das Clínicas da Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
Ocular Immunology and Inflammation
|May 9, 2017
Summary
Intravenous ceftriaxone offers an effective alternative treatment for syphilitic uveitis when penicillin G is unavailable. This study shows significant improvement in ocular inflammation and visual acuity in patients treated with ceftriaxone.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Syphilitic uveitis is a serious ocular condition requiring effective treatment.
- Penicillin G is the standard treatment, but its unavailability necessitates alternative therapeutic options.
Purpose of the Study:
- To evaluate the clinical and multimodal imaging outcomes of patients with syphilitic uveitis treated with intravenous (IV) ceftriaxone.
- To assess the efficacy of IV ceftriaxone as an alternative treatment for syphilitic uveitis.
Main Methods:
- A chart review was conducted for patients diagnosed with syphilitic uveitis between January and August 2014.
- Data collected included clinical, serological, and ophthalmological findings for patients treated with IV ceftriaxone.
Main Results:
- Twelve patients with syphilitic uveitis received IV ceftriaxone (2-4 g daily) for 14-21 days.
- All 24 affected eyes showed improvement in intraocular inflammation.
- Median best-corrected visual acuity improved from 20/50 to 20/20 after a mean follow-up of 5.3 months.
Conclusions:
- Intravenous ceftriaxone demonstrates potential as an effective alternative treatment for syphilitic uveitis.
- This finding is particularly relevant in situations where penicillin G is not accessible.
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