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Analysis of Interventions Required in 12,021 Children With Acute Intoxications Admitted to PICUs
Meral M Patel1, Curtis D Travers, Jana A Stockwell
11Children's Healthcare of Atlanta at Egleston, Division of Critical Care Medicine, Emory University School of Medicine, Department of Pediatrics, Atlanta, GA. 2Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. 3Georgia Poison Center, Atlanta, GA.
Insights
Most pediatric intensive care unit (PICU) admissions for acute intoxications do not require significant interventions. Further research is needed to identify factors influencing the need for PICU interventions in child poisoning cases.
Area of Science:
- Pediatric critical care medicine
- Toxicology
- Public health
Background:
- Acute intoxications represent a significant cause of pediatric intensive care unit (PICU) admissions.
- Understanding the interventions and monitoring for these cases is crucial for optimizing patient care.
Purpose of the Study:
- To describe interventions and monitoring for children admitted to the PICU for intoxications.
- To identify patient and intoxication characteristics associated with the need for PICU interventions.
Main Methods:
- Retrospective review of prospectively collected data from the Virtual Pediatric Systems database.
- Inclusion of patients up to 18 years old admitted to US PICUs between 2011 and 2014 with codes for poisoning, ingestion, intoxication, or overdose.
Main Results:
- A total of 12,021 patients were analyzed, with a median PICU length of stay of 0.97 days.
- Seventy-eight percent of intoxications were intentional, with unknown substances, antidepressants, and other chemicals being the most common ingestions.
- Only 29.1% of cases received interventions, and 0.61% of patients died.
Conclusions:
- The majority of pediatric intoxication admissions to the PICU do not necessitate significant interventions.
- Future research should focus on identifying characteristics that predict the need for PICU intervention to enhance patient safety and resource allocation.
Objectives:
Acute intoxications in children account for 4.6% of annual admissions to the PICU. We aimed to describe the interventions and monitoring required for children admitted to the PICU following intoxications with the ultimate goal of determining patient and intoxication characteristics associated with the need for PICU interventions.
Design:
Retrospective review of prospectively collected data from Virtual Pediatric Systems, LLC.
Setting:
United States PICUs participating in the Virtual Pediatric Systems database from 2011 to 2014.
Patients:
Less than or equal to 18 years old admitted to a PICU with a diagnostic code for poisoning, ingestion, intoxication, or overdose.
Interventions:
None.
Measurements And Main Results:
In total, 12,021 patients were included with a median PICU length of stay of 0.97 days (interquartile range, 0.67-1.60). Seventy-eight percent of the intoxications were intentional. The top five classes of medications ingested were unknown substances (21.6%), antidepressants (11.5%), other chemicals (10.7%), analgesics (7.3%), and antihypertensives (6.2%). Seventy-six (0.61%) patients died. Any of the interventions reported in the Virtual Pediatric Systems database were performed in only 29.1% of the total cases.
Conclusions:
The majority of cases (70.9%) admitted to the PICU following an intoxication did not undergo any significant intervention. Future studies should focus on distinguishing patient and intoxication characteristics associated with need for PICU intervention to optimize patient safety and minimize resource burden.
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